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Resveratrol And The Coming Of Age Of An Unassuming Nutrient
It is likely that until 2009, when CBS’s 60 Minutes twice aired a segment on RESVERATROL, some 17 years after an earlier segment suggested the possible health benefits of drinking red wine, only scientists and academics knew anything about this substance. Resveratrol, derived from grape skins and present in red wine, may have been thought by some to have only modest therapeutic value. But in 2003, two young, enterprising scientists from the Boston area, Christoph Westphal, MD, Ph.D. and David Sinclair, Ph.D., collaborated and discovered that resveratrol may be a major contributor to human longevity. Their research essentially led to the understanding that resveratrol activates a normally dormant gene, the sirtuin gene, which in turn triggers a survival mechanism that improves quality of life.
Clinically speaking, the expected effect of prescribed resveratrol in concentrated form is believed to eliminate the appearance and/or control of age-related diseases. These diseases can include the most dreaded diseases such as cardiovascular, Alzheimer’s, cancer and diabetes to name a few. With this theory in mind, Westphal and Sinclair founded the research company Sirtris Pharmaceuticals, Inc. based in Cambridge, whose aim is to develop a potent synthetic form of resveratrol to treat patients suffering from these diseases. With unlimited potential to patent resveratrol-based prescription drugs, pharmaceutical giant GlaxoSmithKline, and its estimated cash reserves of $9.5 billion, bought Sirtris for nearly three-quarters of a billion dollars and today its founders serve on Sirtris’ scientific advisory board.
Word of resveratrol began to circulate in the mid-1990s despite the fact that no clear explanation for its effectiveness could be offered. Big-name celebrity doctors have praised resveratrol on TV and to their credit have never endorsed any brand, but that hasn’t stopped unscrupulous resveratrol suppliers from claiming that doctors “recommend” their products even to the point of using unauthorized likenesses in their advertising. campaigns. Despite this, neither Sirtris nor GlaxoSmithKline saw fit to issue an over-the-counter version of resveratrol, but a highly concentrated over-the-counter 30-capsule, 250 mg form appeared in the 60 Minutes supplement along with the label statements, “Ultra Pure” and “Supplement nutrition”.
Among those selling their own brand of resveratrol today are online doctors who claim to practice complementary medicine. The resveratrol marketing field is wide open and any establishment selling resveratrol will usually display at least two or three brands with different potencies.
This writer and a colleague specializing in applied kinesiology randomly evaluated brands of resveratrol on store shelves using AK testing techniques. Much to our surprise and delight, only one sample scored consistently high for its clinical efficacy. The brand name is TruNature and the label reads, TruNature Maximum Strength Resveratrol 140 Softgels, 250 mg. — the same strength as the bottle featured in the 60 Minutes segment and labeled “Dietary Supplement.” Interestingly, only this TruNature resveratrol product passed the test. It is sold at Costco and online at amazon.com for about $20 a bottle.
Historically, resveratrol seems to go through the same growing pains as nutrients or biological processes that have proven to be effective therapies. The most prominent example includes the work of the 1998 Nobel Prize in Medicine winner, Ph.D. Louis Ignarro. Dr. Ignarro’s research has shown the signaling (neurotransmitter) properties of nitric oxide (NO) gas in humans and that NO is produced by two relatively inexpensive OTC amino acids, L-argenine and L-citrulline. Although his book “No More Heart Disease – How Nitric Oxide Can Prevent Even Reversed Heart Disease and Strokes” describes ways to increase NO levels and improve the overall health of any person, the big pharmaceutical company Pfizer has taken advantage of Ignarro’s research and is producing a popular and profitable drug Viagra (sildenafil citrate), the first NO-inspired drug designed to increase blood flow in the treatment of erectile dysfunction. Many, perhaps most, men would do just as well taking over-the-counter, non-toxic amino acids instead of toxic drugs that risk permanent side effects. Dr. Ignarro’s books are available online at amazon.com, and his protocol complements over-the-counter resveratrol.
In his farewell address to the nation, President Dwight David Eisenhower warned of possible conflicts of interest in what he called the “Military Industrial Complex.” This term referred to senior military officers who, after retirement, were employed in the defense industry. The same conflict-of-interest scenario appears analogous to senior Food and Drug Administration (FDA) officials retiring from government service and finding lucrative positions in the two industries they were supposed to regulate, a sort of “FDA pharmaceutical complex.”
It’s no secret that the FDA is antagonistic toward the natural health care movement and opposed to covering up industrial abuses such as the continued production of the toxic “food additive” bisphenol A (BPA). Research will inevitably yield breakthroughs in nutritional science, and inevitably the FDA will attempt to exercise its paternalistic Big Brother regulatory role that could threaten the availability of powerful over-the-counter supplements like resveratrol, L-argenine, and L-citrulline. As health-conscious consumers, we must assert our rights and independence to control these forms of over-the-counter dietary supplements and demand that they remain over-the-counter.
To make matters worse, influential Senators Dick Durbin (D-IL) and John McCain (R-AZ) agree with the FDA’s policies and the generous traps the pharmaceutical lobby showers members of Congress with to routinely enact legislation that dilutes the health care freedoms Americans expect and deserve. now taken for granted. If the voters of Illinois and Arizona continue to re-elect these senators, voters in 48 other states have a responsibility, an obligation, to contact members of Congress to replace their initiatives with legislation that strengthens health freedoms and distances the FDA from the natural health protection of communities otherwise only foreign countries will produce OUR nutritional supplements. A watchdog group that reports on legal abuses related to health care is The Alliance For Natural Health (anh-USA.org).
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